Hepatocellular carcinoma (HCC) is the third commonest reason behind cancer-related deaths worldwide. For many intermediate-advanced HCC sufferers, transarterial embolization (TAE) remedy is the mainstream remedy by using embolic brokers to dam the tumor blood provide to induce ischemic necrosis attributing to its minimal invasiveness.
In scientific remedy, transarterial chemoembolization (TACE), which mixes embolic brokers with chemotherapy medication, can also be often adopted to realize improved therapeutic profit. Amongst these clinically used embolic brokers, Lipiodol is a generally used liquid embolic agent for TAE remedy, and it has additionally been collectively utilized with chemotherapeutic medication for TACE.
Nonetheless, the restricted stability of such Lipiodol-drug emulsion at all times led to quick diffusion of medicine from the embolization website, which thereby remarkably weakens the therapeutic efficacy of those chemotherapeutic medication and imposes systemic toxicity. Due to this fact, growth of steady Lipiodol-drug emulsion with sustainable drug launch profiles holds nice promise to method improved remedy of HCCs.
To unravel this difficult downside, in a current analysis article revealed in Nationwide Science Evaluation, a collaborative analysis group led by Professor Zhuang Liu from Soochow College (Institute of Purposeful Nano & Tender Supplies, FUNSOM) proposed a water-in-oil Lipiodol Pickering emulsion stabilized by calcium carbonate nanoparticles and hemin.
In contrast with standard Lipiodol emulsion, the obtained Lipiodol Pickering emulsion enabled steady encapsulation of assorted hydrophilic molecules within the aqueous droplets and pH-responsive launch of the encapsulated molecules as a result of presence of CaCO3 nanoparticles.
Impressed by the capability of lipoxygenase (LOX) in selling the technology of cytotoxic lipid radicals from polyunsaturated fatty acidy, a significant part of Lipiodol, a pH-responsive and self-fueling ferroptosis-inducing microreactor (coined as LHCa-LPE) was concisely constructed by encapsulating LOX with such Lipiodol based mostly Pickering emulsion.
Such LHCa-LPE was proven to be able to successfully inducing ferroptosis of most cancers cells with Lipiodol because the supply of PUFAs by way of the cascading lipid peroxidation chain response. Upon transarterial embolization, such LHCa-LPE may successfully suppress the expansion of orthotopic N1S1 HCC in rats by serving as bifunctional embolic and ferroptosis-inducing brokers.
General, this research highlights a facile technique to organize steady Lipiodol based mostly embolic agent, which can also be promising for potential scientific translation as a result of all parts in such emulsions have glorious biocompatibility, holding nice promise for scientific translation.
Chunjie Wang et al, Self-fueling ferroptosis-inducing microreactors based mostly on pH-responsive Lipiodol Pickering emulsions allow transarterial ferro-embolization remedy, Nationwide Science Evaluation (2023). DOI: 10.1093/nsr/nwad257
Science China Press
Nano-CaCO₃ stabilized ferroptosis-inducing Lipiodol based mostly microreactors for TAFE remedy (2023, November 14)
retrieved 14 November 2023
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